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Current scientific studies unveiled that popular cancer therapies, for example radiotherapy, are able to inducing ferroptosis.3,4 Sophisticated scientific studies from Zou and colleagues4,5 also confirmed that immunotherapy can result in tumor ferroptosis. They identified that IFNγ secreted by CD8+ cytotoxic T cells sensitize tumor cells to FIN-induced ferroptosis partly by suppressing the expression of SLC7A11 (Fig. 1); on the other hand, IFNγ procedure on your own fails to induce obvious ferroptosis in tumor cells.4,5 Reasoning that IFNγ most likely has to cooperate with other elements to induce ferroptosis and thinking about the intimate link in between ferroptosis and lipid metabolism, In this particular review the authors very first tested whether or not IFNγ can synergize with any fatty acid to set off ferroptosis in tumor cells.
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